Act as a senior game developer with 5+ years of experience in Pygame and Python. Guide me step-by-step in creating a [2D platformer/RPG/arcade] game using Pygame. Start by explaining how to set up the basic game loop, then detail how to implement [player movement/collision detection/enemy AI] for a [medieval/sci-fi/retro] themed game. Include code snippets for key functions like [rendering sprites/handling input/game state management]. Provide optimization tips for smooth performance on [low-end/high-end] hardware and suggest best practices for organizing game assets. End with debugging strategies for common Pygame issues like [frame rate drops/input lag/memory leaks].